N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine
CAS No.:1438075-52-5
Molecular Formula:C₂₅H₂₉ClFN₅O₃
Molecular Weight:501.988
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

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Chemical Property of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

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Technology Process of N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

There total 8 articles about N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.19%

: 912556-91-3
6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine

: 1454307-33-5
tert-butyl 4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazine-6-carboxylate

: 1438075-52-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

Guidance literature:: tert-butyl 4-methyl-2,3,4a,5,7,7a-hexahydropyrrolo[3,4-b][1,4]oxazine-6-carboxylate; With hydrogenchloride; methanol; at 20 ℃; for 1h;

6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1438075-52-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 5 h / 88 °C

2.1: water; sodium hydroxide / methanol / 6 h / 20 °C

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 40 °C

4.1: hydrogenchloride / methanol / 1 h / 20 °C

4.2: 20 h / 90 °C

With hydrogenchloride; water; potassium carbonate; potassium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 179688-53-0
6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

: 1438075-52-5
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl) propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

2.1: isopropyl alcohol / 5 h / 88 °C

3.1: water; sodium hydroxide / methanol / 6 h / 20 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 40 °C

5.1: hydrogenchloride / methanol / 1 h / 20 °C

5.2: 20 h / 90 °C

With hydrogenchloride; thionyl chloride; water; potassium carbonate; potassium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;