methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

Base Information

Chemical Name:methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate
CAS No.:957122-16-6
Molecular Formula:C₂₂H₃₂F₂N₂O₄
Molecular Weight:426.504
Hs Code.:

Synonyms:methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

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Chemical Property of methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

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Technology Process of methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

There total 6 articles about methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 37993-32-1
1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

: 957122-16-6
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

Guidance literature:: tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate; 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride; With acetic acid; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 1h; pH=5;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

: 123577-99-1
3′,5′-difluoroacetophenone

: 957122-16-6
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / titanium(IV) isopropylate / ethanol / 20 h / 20 °C

1.2: 2 h / Cooling

2.1: dichloromethane / 0 - 20 °C

2.2: 60 - 70 °C

3.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

3.2: -78 - 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

5.1: acetic acid / methanol / 0.5 h / 20 °C

5.2: 1 h / 20 °C / pH 5

With lithium aluminium tetrahydride; potassium tert-butylate; ammonia; acetic acid; titanium(IV) isopropylate; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 957122-16-6
methyl 1-{[2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propyl]amino}cyclohexane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 0 - 20 °C

1.2: 60 - 70 °C

2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C

2.2: -78 - 0 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

4.1: acetic acid / methanol / 0.5 h / 20 °C

4.2: 1 h / 20 °C / pH 5

With lithium aluminium tetrahydride; potassium tert-butylate; acetic acid; In tetrahydrofuran; methanol; dichloromethane;