N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

Base Information

Chemical Name:N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide
CAS No.:881921-16-0
Molecular Formula:C₂₀H₃₅NO
Molecular Weight:305.504
Hs Code.:

Synonyms:N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

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Chemical Property of N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

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Technology Process of N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

There total 5 articles about N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 881920-78-1
(1S,2S,4R)-2-((R,E)-3-isocyanato-3-methylhex-1-enyl)-1-isopropyl-4-methylcyclohexane

: 1826-67-1
vinyl magnesium bromide

: 881921-16-0
N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/ol053061g DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: 881920-66-7
(S,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-2-en-1-ol

: 881921-16-0
N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 1 h / 0 °C

1.2: potassium carbonate / methanol; H₂O / 0 - 20 °C

1.3: 95 percent / TFAA; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

2.1: 96 percent / tetrahydrofuran / 2 h / 0 °C

In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.jorganchem.2006.07.028

Reference yield:

: 881920-72-5
(S,E)-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-2-enyl carbamate

: 881921-16-0
N-((R,E)-1-((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)-3-methylhex-1-en-3-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / trifluoroacetic anhydride; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

2: 96 percent / tetrahydrofuran / 2 h / 0 °C

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol053061g