5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

Base Information

Chemical Name:5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside
CAS No.:1410808-03-5
Molecular Formula:C₁₇H₁₉F₃N₂O₇
Molecular Weight:420.342
Hs Code.:

Synonyms:5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

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Chemical Property of 5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

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Technology Process of 5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

There total 6 articles about 5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4-(2-benzyloxyphenylmethyl)-5-trifluoromethyl-1H-pyrazol-3-yl β-d-glucopyranoside

: 1410808-03-5
5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;
DOI:10.1016/j.bmc.2012.09.037

Reference yield:

: 478190-62-4
4-(2-benzyloxyphenylmethyl)-5-trifluoromethyl-1,2-dihydro-3H-pyrazol-3-one

: 1410808-03-5
5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / water; dichloromethane / 20 °C

2: sodium methylate; methanol / 21 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With methanol; palladium 10% on activated carbon; hydrogen; sodium methylate; benzyltri(n-butyl)ammonium chloride; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.09.037

Reference yield:

: 478190-69-1
(2-benzyloxyphenyl)methyl mesylate

: 1410808-03-5
5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.08 h / Cooling with ice

1.2: 11 h / Reflux

2.1: hydrazine hydrate / toluene / 7 h / Reflux

3.1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / water; dichloromethane / 20 °C

4.1: sodium methylate; methanol / 21 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With methanol; palladium 10% on activated carbon; hydrogen; sodium methylate; benzyltri(n-butyl)ammonium chloride; sodium hydride; hydrazine hydrate; sodium hydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.09.037