478190-69-1

Upstream product

• 3381-87-1 2-benzyloxybenzyl alcohol 
• 124-63-0 methanesulfonyl chloride 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 90-02-8 salicylaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 1410806-83-5 C₂₁H₂₂O₄ 
• 1410806-81-3 C₂₂H₂₆O₄ 
• 1410806-80-2 C₂₁H₂₄O₄ 
• 1410806-79-9 C₂₀H₂₂O₄ 
• 1410806-78-8 C₁₉H₂₀O₄ 
• 1410807-50-9 4-(2-benzyloxyphenylmethyl)-5-methyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside 
• 1410807-48-5 4-(2-benzyloxyphenylmethyl)-5-trifluoromethyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside 
• 1410807-12-3 4-(2-benzyloxyphenylmethyl)-1,2-dihydro-5-cyclopropyl-3H-pyrazol-3-one 
• 478190-06-6 4-(2-benzyloxyphenylmethyl)-5-tert-butyl-1,2-dihydro-3H-pyrazol-3-one 
• 478190-61-3 4-(2-benzyloxyphenylmethyl)-1,2-dihydro-5-isopropyl-3H-pyrazol-3-one 
• 478190-35-1 4-(2-benzyloxyphenylmethyl)-5-ethyl-1,2-dihydro-3H-pyrazol-3-one 
• 1410807-08-7 4-(2-benzyloxyphenylmethyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 478190-15-7 4-(2-hydroxyphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl β-d-glucopyranoside 
• 1410808-03-5 5-trifluoromethyl-4-(2-hydroxyphenylmethyl)-1H-pyrazol-3-yl β-d-glucopyranoside 

Relevant academic research and scientific papers

Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry

The over-expression of aminopeptidase N on diverse malignant cells is associated with the tumor angiogenesis and metastasis. In this report, one new series of leucine ureido derivatives containing the triazole moiety was designed, synthesized and evaluated as APN inhibitors. Among them, compound 13v showed the best APN inhibition with an IC50 value of 0.089 ± 0.007 μM, which was two orders of magnitude lower than that of bestatin (IC50 = 9.4 ± 0.5 μM). Compound 13v also showed dose-dependent anti-angiogenesis activities. Even at the lower concentration (10 μM), compound 13v presented similar anti-angiogenesis activity compared with bestatin at 100 μM in both the human umbilical vein endothelial cells (HUVECs) capillary tube formation assay and the rat thoracic aorta rings test. Moreover, compared with bestatin, 13v exhibited comparable, if not better in vivo anti-metastasis activity in a mouse H22 pulmonary metastasis model.

Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandial hyperglycemia. A series of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyran