(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

Base Information

Chemical Name:(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate
CAS No.:1362819-69-9
Molecular Formula:C₂₆H₂₄BrF₂NO₄
Molecular Weight:532.382
Hs Code.:

Synonyms:(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

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Chemical Property of (4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

Chemical Property:

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Technology Process of (4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

There total 7 articles about (4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-bromo-2-hydroxy-4-(4-morpholinylmethyl)benzoic acid lithium salt

: 459-46-1
4-Fluorobenzyl bromide

: 1362819-69-9
(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362819-69-9
(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 24 h / 50 °C

2: bromine / chloroform / 1 h / 0 °C

3: pyridine / 4 h

4: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

5: triethylamine / acetone / 0.5 h

6: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 50 °C

7: potassium carbonate / N,N-dimethyl-formamide

With pyridine; N-Bromosuccinimide; thionyl chloride; water; bromine; potassium carbonate; triethylamine; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4670-56-8
methyl 2-hydroxy-4-methylbenzoate

: 1362819-69-9
(4-fluorophenyl)methyl 5-bromo-2-{[(4-fluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / chloroform / 1 h / 0 °C

2: pyridine / 4 h

3: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

4: triethylamine / acetone / 0.5 h

5: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 50 °C

6: potassium carbonate / N,N-dimethyl-formamide

With pyridine; N-Bromosuccinimide; water; bromine; potassium carbonate; triethylamine; lithium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; N,N-dimethyl-formamide; acetone;