1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

Base Information

Chemical Name:1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene
CAS No.:617705-30-3
Molecular Formula:C₁₄H₁₇IO₂
Molecular Weight:344.192
Hs Code.:

Synonyms:1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

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Chemical Property of 1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

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Technology Process of 1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

There total 7 articles about 1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 617705-29-0
(1R,2S)-2-{[(4-methoxybenzyl)oxy]methyl}cyclopropanecarbaldehyde

: 74-88-4
methyl iodide

: 617705-30-3
1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

Guidance literature:: With chromium dichloride; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1016/S0040-4020(03)00916-5

Reference yield:

: 75-47-8
iodoform

: 617705-29-0
(1R,2S)-2-{[(4-methoxybenzyl)oxy]methyl}cyclopropanecarbaldehyde

: 1-[({(1S,2R)-2-[(Z)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

: 617705-30-3
1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

Guidance literature:: With chromium dichloride; In tetrahydrofuran; at 0 ℃; for 2.5h; Overall yield = 63 percent; Overall yield = 3.2 g; Inert atmosphere;
DOI:10.1021/jacs.0c07094

Reference yield:

: 153861-49-5
(1R,2S,4'S)-1-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-2-(hydroxymethyl)cyclopropane

: 1-[({(1S,2R)-2-[(Z)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

: 617705-30-3
1-[({(1S,2R)-2-[(E)-2-iodoethenyl]cyclopropyl}methoxy)methyl]-4-methoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 23 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; water / 3 h / 23 °C / Inert atmosphere

3: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 3 h / 25 °C / Inert atmosphere

4: chromium dichloride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere

With chromium dichloride; hydrogenchloride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jacs.0c07094