2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

Base Information

Chemical Name:2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole
CAS No.:1365543-35-6
Molecular Formula:C₂₃H₂₈N₄O₅
Molecular Weight:440.499
Hs Code.:

Synonyms:2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

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Chemical Property of 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

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Technology Process of 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

There total 5 articles about 2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 198990-09-9
[2-(4-formyl-phenoxy)-ethyl]-carbamic acid tert-butyl ester

: 660432-02-0
N-methoxy N-methyl 3,4-diaminobenzoic acid amide

: 1365543-35-6
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

Guidance literature:: With sodium metabisulfite; In ethanol; water; for 2h; Reflux;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1365543-35-6
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 12 h / 20 °C

3: sodium metabisulfite / ethanol; water / 2 h / Reflux

With sodium metabisulfite; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 1365543-35-6
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: 5%-palladium/activated carbon; hydrogen / methanol / 40 h / 20 °C

4: sodium metabisulfite / ethanol; water / 2 h / Reflux

With oxalyl dichloride; sodium metabisulfite; 5%-palladium/activated carbon; hydrogen; triethylamine; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2012.01.042