2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

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Chemical Name:2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid
CAS No.:1365543-39-0
Molecular Formula:C₂₈H₂₇N₅O₅
Molecular Weight:513.553
Hs Code.:

Synonyms:2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

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Chemical Property of 2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

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Technology Process of 2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

There total 10 articles about 2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365543-37-8
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazole-5-carbaldehyde

: 619-05-6
3,4-diaminobenzoic acid

: 1365543-39-0
2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

Guidance literature:: With sodium metabisulfite; In ethanol; water; for 12h; Reflux;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 1365543-35-6
2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}-5-[(1-methoxy-1-methylamino)carbonyl]benzimidazole

: 1365543-39-0
2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 0 °C

2: sodium metabisulfite / ethanol; water / 12 h / Reflux

With sodium metabisulfite; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1365543-39-0
2-(2-{4-[2-(1,1-dimethylethoxycarbonylamino)ethoxy]phenyl}benzimidazol-5-yl)benzimidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 4 h / 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 12 h / 20 °C

3: sodium metabisulfite / ethanol; water / 2 h / Reflux

4: diisobutylaluminium hydride / tetrahydrofuran / 3 h / -78 - 0 °C

5: sodium metabisulfite / ethanol; water / 12 h / Reflux

With sodium metabisulfite; diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bmcl.2012.01.042