cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Base Information

Chemical Name:cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine
CAS No.:1202462-50-7
Molecular Formula:C₂₄H₃₃ClN₂O₃
Molecular Weight:432.991
Hs Code.:

Synonyms:cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Suppliers and Price of cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

There total 11 articles about cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202006-81-2
7-chloro-6-fluoro-1-methoxy-isoquinoline

: 1202462-49-4
cis-4-(1-aminopropyl)-4-(tetrahydropyran-4-yl)-cyclohexanol

: 1202462-50-7
cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Guidance literature:: cis-4-(1-aminopropyl)-4-(tetrahydropyran-4-yl)-cyclohexanol; With sodium hydride; In ISOPROPYLAMIDE; mineral oil; at 20 ℃; for 1h;

7-chloro-6-fluoro-1-methoxy-isoquinoline; In ISOPROPYLAMIDE; mineral oil; at 20 ℃;

Reference yield:

: 918490-51-4
7-chloro-6-fluoro-isoquinoline

: 1202462-50-7
cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

2.1: chloroformic acid ethyl ester / -10 °C

2.2: 1 h / -20 °C

3.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 1 h / 20 °C

3.2: 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ISOPROPYLAMIDE; chloroformic acid ethyl ester; mineral oil;

Reference yield:

: 25637-18-7
4-iodotetrahydropyran

: 1202462-50-7
cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(tetrahydro-pyran-4-yl)-cyclohexyl]-propylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C

1.2: 20 °C

2.1: acetic acid / water / 24 h / 100 °C

3.1: sodium tetrahydroborate / ethanol / -70 - 20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

5.1: diethyl ether; toluene / 90 °C / Inert atmosphere

6.1: sodium tetrahydroborate / methanol; diethyl ether; toluene / 20 °C

7.1: hydrogenchloride / diethyl ether; water / 18 h / 20 °C

8.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 1 h / 20 °C

8.2: 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; n-heptane; dichloromethane; ISOPROPYLAMIDE; ethylbenzene; water; toluene; mineral oil;