5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

Base Information

Chemical Name:5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene
CAS No.:146384-37-4
Molecular Formula:C₁₅H₁₈ClNO₂
Molecular Weight:279.766
Hs Code.:

Synonyms:5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

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Chemical Property of 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

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Technology Process of 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

There total 12 articles about 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 143-33-9,25596-52-5
sodium cyanide

: 116022-17-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

: 146384-37-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

Guidance literature:: In dimethyl sulfoxide; at 90 - 95 ℃; for 3h;
DOI:10.1248/cpb.40.2847

Reference yield:

: 141546-70-5
(3S,4R)-5-hydroxy-4-methoxy-3-methylpentanenitrile

: 146384-37-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

Guidance literature:: Multi-step reaction with 2 steps

1: PCC, molecular sieves 4A / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 1.) BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, 0 deg C, 1 h

With n-butyllithium; 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane;

Reference yield:

: 159108-95-9
(+)-methyl (2,3-syn)-2,4-cyanomethoxy-3-methylbutanoate

: 146384-37-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / LiBH₄ / tetrahydrofuran / 12 h / Ambient temperature

2: PCC, molecular sieves 4A / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 1.) BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, 0 deg C, 1 h

With lithium borohydride; n-butyllithium; 4 A molecular sieve; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;