5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

Base Information

Chemical Name:5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene
CAS No.:116022-17-4
Molecular Formula:C₂₁H₂₅ClO₅S
Molecular Weight:424.946
Hs Code.:

Synonyms:5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

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Chemical Property of 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

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Technology Process of 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

There total 4 articles about 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 116022-15-2
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-(4E)-penten-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 116022-17-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

Guidance literature:: With pyridine; for 20h; Ambient temperature;
DOI:10.1248/cpb.40.2847

Reference yield:

: 107494-32-6,4386-18-9,107494-34-8,145554-83-2,145554-84-3
(3R,4S)-3-hydroxy-4-methyldihydrofuran-2(3H)-one

: 116022-17-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

Guidance literature:: Multi-step reaction with 3 steps

1: 5 percent / Ag₂O / dimethylformamide / 5 h / Ambient temperature

2: 1.) n-BuLi / 1.) hexane, THF, 0 deg C, 2.) hexane, THF, RT, 12 h

3: 52 percent / pyridine / 20 h / Ambient temperature

With pyridine; n-butyllithium; silver(l) oxide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.2847

Reference yield:

: 110463-12-2
4-chloro-3-methoxyphenylmethyl(triphenyl)phosphonium bromide

: 116022-17-4
5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, THF, 0 deg C, 2.) hexane, THF, RT, 12 h

2: 52 percent / pyridine / 20 h / Ambient temperature

With pyridine; n-butyllithium;
DOI:10.1248/cpb.40.2847