3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

Base Information

Chemical Name:3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl
CAS No.:1352522-71-4
Molecular Formula:C₄₀H₃₀F₂N₆O₄
Molecular Weight:696.713
Hs Code.:

Synonyms:3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

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Chemical Property of 3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

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Technology Process of 3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

There total 4 articles about 3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 3296-02-4
p-azidofluorobenzene

: 1352817-04-9,219583-12-7,219583-93-4
3,3'-diethynyl-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

: 1352522-71-4
3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.020

Reference yield:

: 219583-08-1,219583-90-1
3,3'-bis((trimethylsilyl)ethynyl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

: 1352522-71-4
3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / dichloromethane / 2 h / Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / Inert atmosphere

With methanol; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 2: Huisgen 1,3-dipolar cycloaddition;
DOI:10.1016/j.tet.2011.11.020

Reference yield:

: 142010-88-6,189518-78-3,219583-87-6
(rac)-3,3’-diiodo-2,2’-di(methoxymethoxy)-1,1’-binaphthyl

: 1352522-71-4
3,3'-bis(1-(p-fluorophenyl)-1H-1,2,3-triazol-4-yl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 15 h / Inert atmosphere

2: methanol; potassium carbonate / dichloromethane / 2 h / Inert atmosphere

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / Inert atmosphere

With methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Sonogashira coupling / 3: Huisgen 1,3-dipolar cycloaddition;
DOI:10.1016/j.tet.2011.11.020