3296-02-4

Basic information

• Product Name: 1-Azido-4-fluorobenzene solution
• Synonyms: 1-Azido-4-fluorobenzene solution;4-Fluorophenyl azide solution;1-Azido-4-fluorobenzene solution ~0.5 M in tert-butyl methyl ether, >=95.0% (HPLC)
• CAS NO: 3296-02-4
• Molecular Formula: C₆H₄FN₃
• Molecular Weight: 137.1144632
• Mol File: 3296-02-4.mol
• Article Data: 125

Chemical Properties

• Boiling Point: 35-36 °C(Press: 4 Torr)
• Flash Point: -33℃
• Appearance: /
• Density: 1.2232 g/cm3
• Storage Temp.: ?20°C
• BRN: 1939307
• CAS DataBase Reference: 1-Azido-4-fluorobenzene solution(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azido-4-fluorobenzene solution(3296-02-4)
• EPA Substance Registry System: 1-Azido-4-fluorobenzene solution(3296-02-4)

Safety Data

• Hazard Codes: F,T
• Statements: 11-38-48/23/24/25
• Safety Statements: 16
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 3296-02-4(Hazardous Substances Data)

Usage

General Description

1-Azido-4-fluorobenzene solution is a chemical compound with the molecular formula C6H4FN3. It is a colorless to pale yellow liquid that is used as a reagent in organic chemistry for various transformations, including the synthesis of pharmaceutical compounds and materials. 1-Azido-4-fluorobenzene solution is a highly reactive compound due to the presence of the azide functional group, and it should be handled with caution due to its potential explosive nature. It should be stored and handled in a well-ventilated area, away from sources of heat or ignition. Protective equipment, such as gloves and safety goggles, should be worn when working with this compound. Additionally, appropriate safety measures should be taken to prevent accidental exposure, ingestion, or inhalation of the solution, and it should be disposed of in accordance with local regulations for hazardous waste.

Upstream product

• 371-40-4 4-fluoroaniline 
• 1765-93-1 4-fluoroboronic acid 
• 403-33-8 methyl 4-flurobenzoate 
• 371-14-2 4-fluorophenylhydrazine 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 20893-71-4 4-fluorophenyldiazonium chloride 
• 352-34-1 4-fluoro-1-iodobenzene 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 2146-07-8 p-fluoroaniline hydrochloride 
• 53243-78-0 p-Fluorophenyl-lead triacetate 

Downstream Products

• 371-40-4 4-fluoroaniline 
• 2806-12-4 4-fluoro-N-propylaniline 
• 136684-94-1 cyclohexyl-(4-fluorophenyl)-amine 
• 345204-03-7 (2S,5R,6R)-6-{[1-(4-Fluoro-phenyl)-1H-[1,2,3]triazol-4-yl]-hydroxy-methyl}-3,3-dimethyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 351-83-7 4'-fluoroacetanilide 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 83258-12-2 1-(p-fluorophenyl)-5-(2,2-dimethyltetrahydropyran-4-yl)triazole 
• 83258-13-3 1-(p-fluorophenyl)-4-(2,2-dimethyltetrahydropyran-4-yl)triazole 
• 83258-10-0 1-(p-fluorophenyl)-5-(2,2-dimethyltetrahydropyran-4-yl)triazole-4-carboxylic acid 
• 83258-11-1 1-(p-fluorophenyl)-4-(2,2-dimethyltetrahydropyran-4-yl)triazole-5-carboxylic acid 
• 68695-67-0 4-[3-(4-fluoro-phenyl)-5-methyl-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholin-3-one 
• 136347-48-3 1-[3-(4-fluoro-phenyl)-5-methyl-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-piperidine 
• 864866-22-8 1-(4-fluorophenyl)-5-methyl-4-tributylstanyl-1H-[1,2,3]triazole 
• 116529-14-7 1-(4'-fluorophenyl)-4-phenyl-1H-1,2,3-triazole 

Relevant articles and documents

Mechanisms involved in the antinociceptive and anti-inflammatory effects of a new triazole derivative: 5-[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole (LQFM-096)

The aim of this study was to design, synthesize and evaluate the potential analgesic and anti-inflammatory effects of 5-[1-(4-fluorphenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole—(LQFM-096: a new triazole compound) as well as to elucidate its possible mechani

Synthesis and rational design of new appended 1,2,3-triazole-uracil ensembles as promising anti-tumor agents via in silico vegfr-2 transferase inhibition

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles 5a–r were designed and synthesized via the click reaction. The ligands were well characterized using1 H-,13 C-NMR, elemental analysis and ESI-mass spectrometry. The in silico binding propinquities of the ligands were studied sequentially in the active region of VEGFR-2 using the Molegro virtual docker. All the compounds produced remarkable interactions and potentially inhibitory ligands against VEGFR-2 were obtained with high negative binding energies. Drug-likeness was assessed from the ADME properties. Cytotoxicity of the test compounds was measured against HeLa and HUH-7 tumor cells and NIH/3T3 normal cells by MTT assay. Compound 5h showed higher growth inhibition activity than the positive control, 5-fluorouracil (5-FU), against both HeLa and HUH-7 cells with IC50 values of 4.5 and 7.7 μM respectively. Interestingly, the compounds 5a–r did not show any cytotoxicity towards the normal cell lines. The results advance the position of substituted triazoles in the area of drug design with no ambiguity.

Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof

The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a