(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Base Information

Chemical Name:(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one
CAS No.:1613258-22-2
Molecular Formula:C₂₇H₃₄N₆O₄
Molecular Weight:506.605
Hs Code.:

Synonyms:(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

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Chemical Property of (S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

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Technology Process of (S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

There total 6 articles about (S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613260-13-1
(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

: 506-59-2
N,N-dimethylammonium chloride

: 1613258-22-2
(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 170 ℃; for 0.5h; Sealed tube; Microwave irradiation;

Reference yield:

: 1379338-74-5
5,7-dichloropyrido[3,4-b]pyrazine

: 1613258-22-2
(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 13 h / 100 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

4: triethylamine / dichloromethane / 4 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 170 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1400589-51-6
1,1-dimethylethyl (2S)-2-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-4-morpholinecarboxylate

: 1613258-22-2
(S)-3-(dimethylamino)-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 13 h / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 4 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 170 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;