(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Base Information

Chemical Name:(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one
CAS No.:1613260-13-1
Molecular Formula:C₂₅H₂₈ClN₅O₄
Molecular Weight:497.981
Hs Code.:

Synonyms:(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

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Chemical Property of (S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

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Technology Process of (S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

There total 5 articles about (S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613260-12-0
(S)-2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholine

: 625-36-5
2-chloropropionyl chloride

: 1613260-13-1
(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1379338-74-5
5,7-dichloropyrido[3,4-b]pyrazine

: 1613260-13-1
(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 40 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 13 h / 100 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

4: triethylamine / dichloromethane / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1400589-51-6
1,1-dimethylethyl (2S)-2-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-4-morpholinecarboxylate

: 1613260-13-1
(S)-3-chloro-1-(2-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yloxy)methyl)morpholino)propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 13 h / 100 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 4 h / 20 °C

3: triethylamine / dichloromethane / 4 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;