N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

Base Information

Chemical Name:N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide
CAS No.:97133-74-9
Molecular Formula:C₁₈H₁₈N₂O₅
Molecular Weight:342.351
Hs Code.:

Synonyms:N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

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Technology Process of N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

There total 8 articles about N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 122-04-3
4-nitro-benzoyl chloride

: 97133-63-6
trans-2-amino-trans-5-phenoxycyclopentanol

: 97133-74-9
N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; diethyl ether; for 0.166667h;
DOI:10.1021/jo00217a017

Reference yield:

: 3212-60-0,6426-28-4,62894-08-0,109431-72-3
cyclopent-2-enol

: 97133-74-9
N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / vanadyl acetylacetonate, tert-butyl hydroperoxide / benzene / 1.) 80 deg C, 15 min, 2.) 40 deg C, 5 h

2: 79.5 percent / triphenylphosphine, isopropyl azocarboxylate / tetrahydrofuran / 24 h / Ambient temperature

3: 87 percent / sodium azide, ammonium chloride / ethanol; H₂O / 16 h / Heating

4: hydrogen / 5percent Pd/C / ethanol / 16 h

5: 75 percent / triethylamine / diethyl ether; tetrahydrofuran / 0.17 h

With tert.-butylhydroperoxide; sodium azide; di-isopropyl azodicarboxylate; vanadyl acetylacetonate; ammonium chloride; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1021/jo00217a017

Reference yield:

: 25484-62-2,29782-88-5,765-54-8,25516-47-6,34310-95-7,120577-03-9,139015-06-8
cis-6-oxabicyclo<3.1.0>cyclohexan-2-ol

: 97133-74-9
N-(trans-2-hydroxy-cis-3-phenoxycyclopentyl)-4-nitrobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 79.5 percent / triphenylphosphine, isopropyl azocarboxylate / tetrahydrofuran / 24 h / Ambient temperature

2: 87 percent / sodium azide, ammonium chloride / ethanol; H₂O / 16 h / Heating

3: hydrogen / 5percent Pd/C / ethanol / 16 h

4: 75 percent / triethylamine / diethyl ether; tetrahydrofuran / 0.17 h

With sodium azide; di-isopropyl azodicarboxylate; ammonium chloride; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1021/jo00217a017