3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Base Information

Chemical Name:3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole
CAS No.:1239956-61-6
Molecular Formula:C₂₄H₂₀F₃N₃O₂S
Molecular Weight:471.503
Hs Code.:

Synonyms:3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

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Chemical Property of 3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

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Technology Process of 3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

There total 4 articles about 3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 883019-45-2
5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1239956-61-6
3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: With triethylamine; In dichloromethane; for 2h;

Reference yield:

: 883019-31-6
4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide

: 1239956-61-6
3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 3 h / Reflux

1.2: pH 5 / Cooling

2.1: triethylamine / dichloromethane / 2 h

With triethylamine; sodium hydroxide; In dichloromethane;

Reference yield:

: 60075-23-2
3,4-dimethoxyphenylacetic acid hydrazide

: 1239956-61-6
3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / Reflux

2.1: sodium hydroxide / 3 h / Reflux

2.2: pH 5 / Cooling

3.1: triethylamine / dichloromethane / 2 h

With triethylamine; sodium hydroxide; In ethanol; dichloromethane;