N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide
• CAS No.: 237750-79-7
• Molecular Formula: C₂₃H₂₀N₄O₂S
• Molecular Weight: 416.503
• Mol file: 237750-79-7.mol

Synonyms:N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

Chemical Property of N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide

There total 6 articles about N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]benzenesulfonamide (236417-29-1) + methyl iodide (74-88-4) → N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide (237750-79-7)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 5h;

DOI:10.1021/jm0109513

Reference yield:

4-cyanophenylacetic acid (5462-71-5) → N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide (237750-79-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 0.5 h / 50 °C

1.2: 79 percent / tetrahydrofuran / 2 h / 50 °C

2.1: 93 percent / glacial acetic acid / 1 h / Heating

3.1: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

4.1: 91 percent / pyridine / 1 h / 20 °C

5.1: 83 percent / K₂CO₃ / acetone / 5 h / 20 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1021/jm0109513

Reference yield:

N1-methyl-4-nitrobenzene-1,2-diamine (41939-61-1) → N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-N-methyl-benzenesulfonamide (237750-79-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 0.5 h / 50 °C

1.2: 79 percent / tetrahydrofuran / 2 h / 50 °C

2.1: 93 percent / glacial acetic acid / 1 h / Heating

3.1: 100 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂

4.1: 91 percent / pyridine / 1 h / 20 °C

5.1: 83 percent / K₂CO₃ / acetone / 5 h / 20 °C

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1021/jm0109513

upstream raw materials:

N-[2-(4-cyano-benzyl)-1-methyl-1H-benzoimidazol-5-yl]benzenesulfonamide

methyl iodide

4-cyanophenylacetic acid

N₁-methyl-4-nitrobenzene-1,2-diamine