Technology Process of 6,7-diethoxy-4-(3,4,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid
There total 6 articles about 6,7-diethoxy-4-(3,4,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-[4,5-diethoxy-2-(3,4,5-trimethoxy-benzoyl)-benzoyloxy]-malonic acid di-tert-butyl ester;
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
With
acetic acid;
In
1,4-dioxane;
for 6h;
Further stages.;
Heating;
DOI:10.1021/jm000558h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: tetrahydrofuran / 0.5 h / -40 °C
2.1: 2 N HCl / tetrahydrofuran / 20 °C
3.1: resorcinol; acetate buffer; NaClO2 / dioxane; H2O / 20 °C / pH 3.8
4.1: K2CO3 / dimethylformamide / 20 °C
5.1: 4 N HCl / ethyl acetate / 20 °C
5.2: AcOH / dioxane / 6 h / Heating
With
hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; recorcinol;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
1.2: tetrahydrofuran / 0.5 h / -40 °C
2.1: 2 N HCl / tetrahydrofuran / 20 °C
3.1: resorcinol; acetate buffer; NaClO2 / dioxane; H2O / 20 °C / pH 3.8
4.1: K2CO3 / dimethylformamide / 20 °C
5.1: 4 N HCl / ethyl acetate / 20 °C
5.2: AcOH / dioxane / 6 h / Heating
With
hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; recorcinol;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h
![2-[4,5-diethoxy-2-(3,4,5-trimethoxy-benzoyl)-benzoyloxy]-malonic acid di-<i>tert</i>-butyl ester](/Databaselist/images/loading.webp)
