(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide

Base Information

• Chemical Name: (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide
• CAS No.: 1234714-55-6
• Molecular Formula: C₃₅H₄₁NO₆
• Molecular Weight: 571.714
• Mol file: 1234714-55-6.mol

Synonyms:(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide

Chemical Property of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide

There total 1 articles about (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(3''',4'''-dimethoxybenzyloxy)acetamide (1234713-93-9) + benzaldehyde (100-52-7) + methyl iodide (74-88-4) → (S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide (1234714-55-6) + C35H41NO6 (1234714-56-7)

Guidance literature:

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(3''',4'''-dimethoxybenzyloxy)acetamide; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; at -78 ℃;

methyl iodide; optical yield given as %de; diastereoselective reaction; Further stages;

DOI:10.1016/j.tet.2010.03.105

Reference yield: 91.0%

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide (1234714-55-6) → C16H21NO (1177266-30-6) + C19H22O5

Guidance literature:

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl (2R,3S)-2-(3''',4'''-dimethoxybenzyloxy)-3-methoxy-3-phenylpropanamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

In tetrahydrofuran; at 0 ℃; pH=7; phosphate buffer;

DOI:10.1016/j.tet.2010.03.105

upstream raw materials:

(S)-N-tert-butoxy-N-1'-(1''-naphthyl)ethyl 2-(3''',4'''-dimethoxybenzyloxy)acetamide

benzaldehyde

methyl iodide

Downstream raw materials:

C₁₆H₂₁NO