2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Base Information

Chemical Name:2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline
CAS No.:1554015-66-5
Molecular Formula:C₂₄H₃₁ClFN₃O
Molecular Weight:431.981
Hs Code.:

Synonyms:2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

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Chemical Property of 2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

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Technology Process of 2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

There total 10 articles about 2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1557207-99-4
1-(1-(2-aminophenyl)-4-chloro-5-fluoro-7-methoxyspiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

: 1554015-66-5
2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1554015-66-5
2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4 h / 23 °C

2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: ethanol / 0.17 h / 20 °C

3.2: 16 h / 20 °C

3.3: 0.5 h / 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 100 °C / Inert atmosphere

5.1: iron; ammonium chloride / methanol; water / 5 h / 70 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 16 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1557207-96-1
1-(4-chloro-5-fluoro-7-methoxyspiro[indoline-3,4'-piperidine]-1'-yl)-2,2-dimethylpropan-1-one

: 1554015-66-5
2-[4-chloro-5-fluoro-7-methoxy-1'-neopentyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 100 °C / Inert atmosphere

2: iron; ammonium chloride / methanol; water / 5 h / 70 °C

3: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 16 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; dichloromethane; water; toluene;