1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide

Base Information

• Chemical Name: 1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide
• CAS No.: 138304-95-7
• Molecular Formula: C₂₂H₁₇N₃O₃
• Molecular Weight: 371.395
• Mol file: 138304-95-7.mol

Synonyms:1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide

Chemical Property of 1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide

Chemical Property:

• Vapor Pressure: 4.41E-14mmHg at 25°C
• Boiling Point: 575.4°Cat760mmHg
• Flash Point: 301.8°C
• PSA: 84.22000
• Density: 1.415g/cm³
• LogP: 3.72500

Purity/Quality:

99%min ^*data from raw suppliers

1,2-DIHYDRO-4-HYDROXY-N-(3-METHYLPHENYL)-2-OXO-1-PHENYL-1,8-NAPHTHYRID INE-3-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide

There total 3 articles about 1,2-Dihydro-4-hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1,8-naphthyrid ine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-phenyl-4-hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acid ethyl ester (138305-20-1) + 1-amino-3-methylbenzene (108-44-1) → 4-Hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamide (138304-95-7)

Guidance literature:

In xylene; for 2h; Heating;

DOI:10.1021/jm00084a019

Reference yield: 74.0%

→ 4-Hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamide (138304-95-7)

Guidance literature:

Reference yield:

1-phenyl-2H-pyrido<2,3-d><1,3>oxazine-2,4(1H)-dione (138305-19-8) → 4-Hydroxy-N-(3-methylphenyl)-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamide (138304-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) dimethylacetamide, 2.) dimethylacetamide, 150 deg C, 2.5 h

2: 74 percent / xylene / 2 h / Heating

With sodium hydride; In xylene;

DOI:10.1021/jm00084a019

upstream raw materials:

1-phenyl-4-hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acid ethyl ester

1-amino-3-methylbenzene

1-phenyl-2H-pyrido<2,3-d><1,3>oxazine-2,4(1H)-dione

Refernces

• 1、 -. "Anti-inflammatory 1,8-naphthyridin-2-one derivatives". . . Retrieved 2008/06/13.