A novel synthesis and potent antiinflammatory activity of 4-hydroxy-2(1H)- oxo-1-phenyl-1,8-naphthyridine-3-carboxamides

DOI: 10.1021/jm00084a019

Source and publish data:

Journal of Medicinal Chemistry p. 1130 - 1136 (1992)

Update date:2022-09-26

Topics: Synthesis Reaction Potent Chemical Reaction Activity Chemical compound Antiinflammatory

Authors:

Kuroda Kuroda

Suzuki Suzuki

Tamura Tamura

Ohmori Ohmori

Hosoe Hosoe

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Article abstract of DOI:10.1021/jm00084a019

New antiinflammatory agents 4-hydroxy-2(1H)-oxo-1-phenyl-1,8- naphthyridine-3-carboxamides 7 were designed and synthesized via a valuable intermediate, 1-phenyl-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione (9). The nature of substituents on the amide nitrog

Full text of DOI:10.1021/jm00084a019

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