A novel synthesis and potent antiinflammatory activity of 4-hydroxy-2(1H)- oxo-1-phenyl-1,8-naphthyridine-3-carboxamides

Article abstract of DOI:10.1021/jm00084a019

New antiinflammatory agents 4-hydroxy-2(1H)-oxo-1-phenyl-1,8- naphthyridine-3-carboxamides 7 were designed and synthesized via a valuable intermediate, 1-phenyl-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione (9). The nature of substituents on the amide nitrog