(S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate

Base Information

• Chemical Name: (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate
• CAS No.: 155729-07-0
• Molecular Formula: C₁₅H₂₂O₄S
• Molecular Weight: 298.403
• Mol file: 155729-07-0.mol

Synonyms:(S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate

Chemical Property of (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate

There total 3 articles about (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-4-(Toluene-4-sulfonyl)-butan-2-ol (131701-86-5) + butyryl chloride (141-75-3) → (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate (155729-07-0)

Guidance literature:

With triethylamine; In diethyl ether; for 6h; Ambient temperature;

DOI:10.1021/jo00087a014

Reference yield:

4-[(4'-methylphenyl)sulfonyl]-2-butanone (61476-94-6) → (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate (155729-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: baker's yeast reduction

2: 84 percent / Et₃N / diethyl ether / 6 h / Ambient temperature

With triethylamine; In diethyl ether;

DOI:10.1021/jo00087a014

Reference yield:

2,2,2-trichloroethyl butyrate (57392-44-6) + (3-hydroxy)butyl p-tolyl sulfone (105363-56-2) → (S)-4-(Toluene-4-sulfonyl)-butan-2-ol (131701-86-5) + (S)-1-Methyl-3-(p-tolylsulfonyl)propyl butanoate (155729-07-0) + Butyric acid (R)-1-methyl-3-(toluene-4-sulfonyl)-propyl ester

Guidance literature:

With 4 A molecular sieve; In diethyl ether; for 3h; Title compound not separated from byproducts; Heating; porcine pancreatic lipase;

DOI:10.1016/0957-4166(90)80004-I

upstream raw materials:

2,2,2-trichloroethyl butyrate

(3-hydroxy)butyl p-tolyl sulfone

(S)-4-(Toluene-4-sulfonyl)-butan-2-ol

butyryl chloride