1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

Base Information

Chemical Name:1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate
CAS No.:1044277-10-2
Molecular Formula:C₁₆H₁₈F₃NO₄Si
Molecular Weight:373.404
Hs Code.:

Synonyms:1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

Chemical Property:

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Technology Process of 1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

There total 2 articles about 1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044277-02-2
3-(trifluoromethyl)-1-(trimethylsilyl)pent-1-yn-3-ol

: 122-04-3
4-nitro-benzoyl chloride

: 1044277-10-2
1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

Guidance literature:: 3-(trifluoromethyl)-1-(trimethylsilyl)pent-1-yn-3-ol; 4-nitro-benzoyl chloride; In tetrahydrofuran; tert-butyl methyl ether; at -30 - 5 ℃; for 4h;

With water; In tetrahydrofuran; tert-butyl methyl ether;

Reference yield:

: 381-88-4
1,1,1-trifluoro-2-butanone

: 122-04-3
4-nitro-benzoyl chloride

: 1066-54-2
trimethylsilylacetylene

: 1044277-10-2
1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tert-butyl methyl ether; at -67 - -51 ℃; for 6.75h; Large scale reaction;

1,1,1-trifluoro-2-butanone; In tert-butyl methyl ether; at -65 - -50 ℃; for 4.33h; Large scale reaction;

4-nitro-benzoyl chloride; In tetrahydrofuran; tert-butyl methyl ether; at -33 ℃; for 6.5h; Large scale reaction;
DOI:10.1021/op200299p

Reference yield:

: 1044277-10-2
1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate

: 1044277-05-5
(R)-1-ethyl-1-(trifluoromethyl)prop-2-yn-1-yl 4-nitrobenzoate

: 1044277-04-4
(S)-1-ethyl-1-(trifluoromethyl)prop-2-yn-1-yl 4-nitrobenzoate

Guidance literature:: 1-ethyl-1-(trifluoromethyl)-3-(trimethylsilyl)prop-2-yn-1-yl 4-nitrobenzoate; With potassium phosphate; water; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide; at 0 ℃; for 1.5h; Resolution of racemate;

With hydrogenchloride; water; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide; at 0 - 2 ℃; Product distribution / selectivity;