ethacraplatin

Base Information

• Chemical Name: ethacraplatin
• CAS No.: 847227-34-3
• Molecular Formula: C₂₆H₂₈Cl₆N₂O₈Pt
• Molecular Weight: 904.315
• Mol file: 847227-34-3.mol

Synonyms:ethacraplatin

Chemical Property of ethacraplatin

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethacraplatin

There total 1 articles about ethacraplatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis,cis,trans-diamminedichlorodihydroxy platinum(IV) + <2,3-dichloro-4-(2-methylenebutyryl)phenoxy>acetyl chloride (113239-57-9) → ethacraplatin (847227-34-3)

Guidance literature:

In not given;

DOI:10.1021/ja0432618

Reference yield:

ethacraplatin (847227-34-3) → cisplatine (26035-31-4,14913-33-8,15663-27-1) + ethacrynic acid (58-54-8)

Guidance literature:

With sodium L-ascorbate; In tetrahydrofuran; aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; pH=7.4; Kinetics;

DOI:10.1002/cmdc.201800105

upstream raw materials:

<2,3-dichloro-4-(2-methylenebutyryl)phenoxy>acetyl chloride

Downstream raw materials:

cisplatine

ethacrynic acid

Refernces

• 1、 Wee, Han Ang,Khalaila, Isam,Allardyce, Claire S.,Juillerat-Jeanneret, Lucienne,Dyson, Paul J.. "Rational design of platinum(IV) compounds to overcome glutathione-S- transferase mediated drug resistance". . p. 1382 - 1383. Retrieved 2007/10/03.