azane;dichloroplatinum

Base Information

• Chemical Name: azane;dichloroplatinum
• CAS No.: 26035-31-4
• Molecular Formula: Cl₂H₆N₂Pt
• Molecular Weight: 300.047
• Wikidata: Q412415
• Mol file: 26035-31-4.mol

Synonyms:trans-DDP;trans-diamminedichloroplatinum II;trans-dichlorodiammineplatinum II;transplatin

Chemical Property of azane;dichloroplatinum

Chemical Property:

• PSA: 52.04000
• LogP: 1.59590
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 298.955598
• Heavy Atom Count: 5
• Complexity: 2.8

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: N.N.Cl[Pt]Cl
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Technology Process of azane;dichloroplatinum

There total 115 articles about azane;dichloroplatinum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

cis-diaminediiodoplatinum(II) + potassium chloride → cisplatine (26035-31-4,14913-33-8,15663-27-1)

Guidance literature:

cis-diaminediiodoplatinum(II); With silver sulfate; In water; at 80 ℃;

potassium chloride; In water; at 80 ℃; for 0.333333h;

DOI:10.1021/jacs.9b10319

Reference yield:

ethacraplatin (847227-34-3) → cisplatine (26035-31-4,14913-33-8,15663-27-1) + ethacrynic acid (58-54-8)

Guidance literature:

With sodium L-ascorbate; In tetrahydrofuran; aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; pH=7.4; Kinetics;

DOI:10.1002/cmdc.201800105

Reference yield:

C13H18Cl4N2O5Pt → cisplatine (26035-31-4,14913-33-8,15663-27-1) + ethacrynic acid (58-54-8)

Guidance literature:

With sodium L-ascorbate; In aq. phosphate buffer; at 20 ℃; pH=7.4; Kinetics;

DOI:10.1002/cmdc.201800105

upstream raw materials:

platinum(II) chloride

ammine of zinc platinum(II) chloride

cis-diamminetetrachloroplatinum(IV)

Downstream raw materials:

(OC-6-33)-(diammine)dichloridodihydroxidoplatinum(IV)

platinum

trans-Pt(NH₃)2Br₄

trans-diamminetetrachloroplatinum(IV)

Refernces

• 1、 Buslaeva, T. M.,Fesik, E. V.,Melnikova, T. I.,Tarasova, L. S.. "Solid-Phase Reaction of Tetraammineplatinum(II) Chloride with Ammonium Heptamolybdate". . p. 1020 - 1024. Retrieved 2020/07/27.
• 2、 Sutton, Emily C.,Mcdevitt, Christine E.,Prochnau, Jack Y.,Yglesias, Matthew V.,Mroz, Austin M.,Yang, Min Chieh,Cunningham, Rachael M.,Hendon, Christopher H.,Derose, Victoria J.. "Nucleolar Stress Induction by Oxaliplatin and Derivatives". supporting information. p. 18411 - 18415. Retrieved 2019/11/19.