Z-Ile-OSu

Base Information

• Chemical Name: Z-Ile-OSu
• CAS No.: 3391-99-9
• Molecular Formula: C18H22 N2 O6
• Molecular Weight: 362.382
• European Community (EC) Number: 222-228-1
• Nikkaji Number: J205.486H
• Mol file: 3391-99-9.mol

Synonyms:Z-Ile-OSu;3391-99-9;Z-Isoleucine-osu;SCHEMBL2579674;MFCD00079002;AKOS016003296;FD21816;AS-49210;CS-0204427;A875146;J-019378;2,5-dioxopyrrolidin-1-yl ((benzyloxy)carbonyl)-l-isoleucinate;N-alpha-BenZyloxycarbonyl-L-isoleucine sucinimidyl ester (CbZ-L-Ile-OSu);(2S,3S)-2,5-dioxopyrrolidin-1-yl 2-(benzyloxycarbonylamino)-3-methylpentanoate

Chemical Property of Z-Ile-OSu

Chemical Property:

• Melting Point: 111-112 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 102.01000
• Density: 1.27g/cm³
• LogP: 2.26350
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 362.14778643
• Heavy Atom Count: 26
• Complexity: 528

Purity/Quality:

97% ^*data from raw suppliers

Z-L-isoleucine-N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)ON1C(=O)CCC1=O)NC(=O)OCC2=CC=CC=C2
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)ON1C(=O)CCC1=O)NC(=O)OCC2=CC=CC=C2

Technology Process of Z-Ile-OSu

There total 5 articles about Z-Ile-OSu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-Cbz-L-Isoleucine (3160-59-6) → N-Z-L-isoleucine N-hydroxysuccinimide ester (3391-99-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 5 ℃; for 3h;

DOI:10.1039/c4ob02003k

Reference yield:

N-Cbz-L-Isoleucine (3160-59-6) → N-Z-L-isoleucine N-hydroxysuccinimide ester (3391-99-9)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 5h;

DOI:10.1039/c0sm01293a

Reference yield:

di(succinimido) carbonate (74124-79-1) + N-Cbz-L-Isoleucine (3160-59-6) → N-Z-L-isoleucine N-hydroxysuccinimide ester (3391-99-9)

Guidance literature:

With pyridine; In acetonitrile;

DOI:10.1016/j.bmcl.2008.09.006

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-benzyloxycarbonyl-L-isoleucine

N-Cbz-L-Isoleucine

di(succinimido) carbonate

Downstream raw materials:

Z-Ile-Ile-OH

N-Benzyloxycarbonyl-L-isoleucyl-L-valin

Z-Ile-Leu-Tyr-OH

Z-Ile-Pro-OH

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