((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

Base Information

Chemical Name:((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine
CAS No.:271247-18-8
Molecular Formula:C₂₈H₂₇F₃N₆
Molecular Weight:504.558
Hs Code.:

Synonyms:((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

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Chemical Property of ((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

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Technology Process of ((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

There total 8 articles about ((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 271247-36-0
(S)-3-(3-trifluoromethylphenyl)-4-[(2-α-methylbenzylamino)pyrimidin-4-yl]-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

: 271247-18-8
((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

Guidance literature:: With hydrogen bromide; acetic acid; at 20 ℃; for 1h;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 4-[5-(2-methylsulfanyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridazin-3-yl]-piperidine-1-carboxylic acid benzyl ester

: 271247-18-8
((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1: DDQ / toluene / 18 h / 20 °C

2: 90 percent / aq. H₂O₂ / sodium tungstate / methanol / 18 h / Heating

3: 125 °C

4: H₂ / Pd/C / 18 h / 20 °C

With hydrogen; dihydrogen peroxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium tungstate; palladium on activated charcoal; In methanol; toluene;
DOI:10.1016/j.bmcl.2005.02.010

Reference yield:

: 200801-88-3
2-(2-Methylsulfanylpyrimidin-4-yl)-1-(3-trifluoromethylphenyl)ethanone

: 271247-18-8
((S)-1-Phenyl-ethyl)-{4-[6-piperidin-4-yl-3-(3-trifluoromethyl-phenyl)-pyridazin-4-yl]-pyrimidin-2-yl}-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

1.2: dimethylsulfoxide / 18 h / 20 °C

2.1: hydrazine / 2-methyl-propan-2-ol / 0.5 h / Heating

2.2: 180 °C / high vacuum

3.1: DDQ / toluene / 18 h / 20 °C

4.1: 90 percent / aq. H₂O₂ / sodium tungstate / methanol / 18 h / Heating

5.1: 125 °C

6.1: H₂ / Pd/C / 18 h / 20 °C

With hydrogen; dihydrogen peroxide; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; sodium tungstate; palladium on activated charcoal; In methanol; dimethyl sulfoxide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.02.010