3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

Base Information

Chemical Name:3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine
CAS No.:271247-34-8
Molecular Formula:C₂₉H₂₆F₃N₅O₂S
Molecular Weight:565.619
Hs Code.:

Synonyms:3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

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Chemical Property of 3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

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Technology Process of 3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

There total 5 articles about 3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[5-(2-methylsulfanyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridazin-3-yl]-piperidine-1-carboxylic acid benzyl ester

: 271247-34-8
3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 20 ℃; for 24h;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 200801-88-3
2-(2-Methylsulfanylpyrimidin-4-yl)-1-(3-trifluoromethylphenyl)ethanone

: 271247-34-8
3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

1.2: dimethylsulfoxide / 18 h / 20 °C

2.1: hydrazine / 2-methyl-propan-2-ol / 0.5 h / Heating

2.2: 180 °C / high vacuum

3.1: DDQ / toluene / 18 h / 20 °C

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; In dimethyl sulfoxide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.02.010

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 271247-34-8
3-(3-trifuoromethylphenyl)-4-(2-methylthiopyrimidin-4-yl)-6-(N-carbobenzoxypiperidin-4-yl)pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

2.1: NaH / dimethylsulfoxide / 0.5 h / 20 °C

2.2: dimethylsulfoxide / 18 h / 20 °C

3.1: hydrazine / 2-methyl-propan-2-ol / 0.5 h / Heating

3.2: 180 °C / high vacuum

4.1: DDQ / toluene / 18 h / 20 °C

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine; lithium diisopropyl amide; In tetrahydrofuran; dimethyl sulfoxide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2005.02.010