4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:195877-38-4
Molecular Formula:C₂₁H₃₀N₂O₆
Molecular Weight:406.479
Hs Code.:

4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 24424-99-5
di-tert-butyl dicarbonate

: 2-amino-3-[4]piperidyl-propionic acid ; dihydrochloride

: 195877-38-4
4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With copper(II) sulfate; Yield given; Multistep reaction;
DOI:10.1016/S0960-894X(99)00179-1

Reference yield: 80.0%

: 67-56-1
methanol

: 195877-38-4
4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 195877-39-5
4-(2-benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1016/S0960-894X(99)00179-1

Reference yield:

: 195877-38-4
4-(2-benzyloxycarbonylamino-2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 3-{[(S)-1-((R)-3-Cyclohexyl-2-ethanesulfonylamino-propionyl)-pyrrolidine-2-carbonyl]-amino}-2-oxo-4-piperidin-4-yl-butyric acid

Guidance literature:: Multi-step reaction with 10 steps

1: 80 percent / TBTU, pH 8.5 / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 100 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3: 100 percent / TEBAC / CH₂Cl₂; H₂O / 0.5 h / 0 °C

4: 89 percent / HCl (gas) / diethyl ether / 16 h / 0 - 5 °C

5: 45 percent / Et₃N, pH 8.5 / dimethylformamide / 1 h / Ambient temperature

6: 100 percent / H₂ / 10 percent Pd/C / dimethylformamide / Ambient temperature

7: 88 percent / HOBT, DCCI / dimethylformamide / a) 0 deg C, 0.5 h, b) RT, 16 h

8: 100 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂ / 0.5 h / Ambient temperature

9: 100 percent / pH 11.5 / dioxane; H₂O / Ambient temperature

10: 36 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; diisobutylaluminium hydride; benzotriazol-1-ol; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00179-1