4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

Base Information

Chemical Name:4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide
CAS No.:83101-55-7
Molecular Formula:C₂₄H₃₁N₃O₃S₂
Molecular Weight:473.66
Hs Code.:

Synonyms:4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

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Chemical Property of 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

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Technology Process of 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

There total 9 articles about 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 83101-43-3
5-(4-Cyanphenyl)-2-tosylaminovaleriansaeurepiperidid

: 83101-55-7
4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

Guidance literature:: With TEA; hydrogen sulfide; In pyridine; Ambient temperature;

Reference yield:

: 1734-79-8
3-(4-nitrophenyl)-2-propenal

: 83101-55-7
4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent / NaBH₄ / methanol

2: 78 percent / H₂ / Raney-Ni / methanol / 760 Torr

3: 1.) HCl/NaNO₂ / 1.) H₂O; 2.) 0-5 deg C 30 min, room temp. 4 h

4: PBr₃ / CHCl₃ / 1.5 h / Heating

5: C₂H₂ONa / ethanol / 5 h / Heating

6: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et₂O, room temp. 2 h

7: SOCl₂ / 1 h / Heating

8: 36 percent / benzene / 1.5 h / Ambient temperature

9: 65 percent / TEA, H₂S / pyridine / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; C₂H₂ONa; TEA; hydrogen sulfide; hydrogen; phosphorus tribromide; sodium nitrite; nickel; In pyridine; methanol; ethanol; chloroform; benzene;

Reference yield:

: 35271-56-8,142917-82-6,1504-63-8
3-(4-nitrophenyl)propyl-2-en-1-ol

: 83101-55-7
4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / H₂ / Raney-Ni / methanol / 760 Torr

2: 1.) HCl/NaNO₂ / 1.) H₂O; 2.) 0-5 deg C 30 min, room temp. 4 h

3: PBr₃ / CHCl₃ / 1.5 h / Heating

4: C₂H₂ONa / ethanol / 5 h / Heating

5: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et₂O, room temp. 2 h

6: SOCl₂ / 1 h / Heating

7: 36 percent / benzene / 1.5 h / Ambient temperature

8: 65 percent / TEA, H₂S / pyridine / Ambient temperature

With hydrogenchloride; potassium hydroxide; thionyl chloride; C₂H₂ONa; TEA; hydrogen sulfide; hydrogen; phosphorus tribromide; sodium nitrite; nickel; In pyridine; methanol; ethanol; chloroform; benzene;