4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide

Base Information

• Chemical Name: 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide
• CAS No.: 83101-68-2
• Molecular Formula: C₂₅H₃₃N₃O₃S₂*HI
• Molecular Weight: 615.6
• Mol file: 83101-68-2.mol

Synonyms:

Chemical Property of 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide

There total 10 articles about 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide (83101-55-7) + methyl iodide (74-88-4) → 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide (83101-68-2)

Guidance literature:

In acetone; Ambient temperature;

Reference yield:

3-(4-nitrophenyl)propyl-2-en-1-ol (35271-56-8,142917-82-6,1504-63-8) → 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide (83101-68-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 78 percent / H₂ / Raney-Ni / methanol / 760 Torr

2: 1.) HCl/NaNO₂ / 1.) H₂O; 2.) 0-5 deg C 30 min, room temp. 4 h

3: PBr₃ / CHCl₃ / 1.5 h / Heating

4: C₂H₂ONa / ethanol / 5 h / Heating

5: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et₂O, room temp. 2 h

6: SOCl₂ / 1 h / Heating

7: 36 percent / benzene / 1.5 h / Ambient temperature

8: 65 percent / TEA, H₂S / pyridine / Ambient temperature

9: 90 percent / acetone / Ambient temperature

With hydrogenchloride; potassium hydroxide; thionyl chloride; C₂H₂ONa; TEA; hydrogen sulfide; hydrogen; phosphorus tribromide; sodium nitrite; nickel; In pyridine; methanol; ethanol; chloroform; acetone; benzene;

Reference yield:

3-(4-nitrophenyl)-2-propenal (1734-79-8) → 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzimidic acid methyl ester; hydriodide (83101-68-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 70 percent / NaBH₄ / methanol

2: 78 percent / H₂ / Raney-Ni / methanol / 760 Torr

3: 1.) HCl/NaNO₂ / 1.) H₂O; 2.) 0-5 deg C 30 min, room temp. 4 h

4: PBr₃ / CHCl₃ / 1.5 h / Heating

5: C₂H₂ONa / ethanol / 5 h / Heating

6: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et₂O, room temp. 2 h

7: SOCl₂ / 1 h / Heating

8: 36 percent / benzene / 1.5 h / Ambient temperature

9: 65 percent / TEA, H₂S / pyridine / Ambient temperature

10: 90 percent / acetone / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; C₂H₂ONa; TEA; hydrogen sulfide; hydrogen; phosphorus tribromide; sodium nitrite; nickel; In pyridine; methanol; ethanol; chloroform; acetone; benzene;

upstream raw materials:

4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-thiobenzamide

methyl iodide

3-(4-nitrophenyl)propyl-2-en-1-ol

3-(4-nitrophenyl)-2-propenal

Downstream raw materials:

4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-benzamidine; hydriodide