Chemical Property of Cycloheximide
Chemical Property:
- Appearance/Colour:Off-white to light tan powder
- Vapor Pressure:9.81E-12mmHg at 25°C
- Melting Point:111-116 °C
- Refractive Index:1.498
- Boiling Point:491.8 °C at 760 mmHg
- PKA:11.61±0.40(Predicted)
- Flash Point:251.2 °C
- PSA：83.47000
- Density:1.136 g/cm3
- LogP:1.37030
- Storage Temp.:2-8°C
- Solubility.:Soluble in Ethanol (up to 14 mg/ml) or in Water (up to 7 mg/ml).
- Water Solubility.:2.1 g/100 mL (2 ºC)
- XLogP3:0.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:281.16270821
- Heavy Atom Count:20
- Complexity:404
- Transport DOT Label:Poison
- Purity/Quality:
-
99.3% *data from raw suppliers
Cycloheximide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn, 
T, 
N, 
T+
- Hazard Codes:Xn,T,N,T+
- Statements:
22-68-61-51/53-28-38-52/53
- Safety Statements:
53-45-61-36/37-28
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Pesticides -> Plant Growth Regulators
- Canonical SMILES:CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
- Isomeric SMILES:C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
- Inhalation Risk:Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
- Effects of Short Term Exposure:The substance is irritating to the eyes and skin. Exposure could cause death.
-
Description
Cycloheximide is a glutarimide-type antibiotic produced by Streptomyces
griseus. Colorless crystals, C15H23NO4 (281.4), melting
point: 115.5–117 ?C, weak acidic substance (pKa 11.2),
Soluble in chloroform, isopropanol and methanol; water >
21 g/L (2 ?C). Stable in pH 3–5, but rapidly destroyed in
alkaline solutions. Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 μM) by interfering with translational elongation. Its effects on protein synthesis can either induce or inhibit apoptosis depending on cell type. Cycloheximide is widely used as a tool in molecular biology research for ribosome profiling and translational profiling as well as to determine the half-life of a protein.
-
Uses
immunomodulator Cycloheximide is an antibiotic substance isolated from the beers of streptomycin-producing strains of Streptomyces griseus. Cycloheximide is used as fungicide. Cycloheximide is the most recognised member of the glutarimide microbial metabolites. Cycloheximide was isolated from Streptomyces griseus in the late 1940s as a potent and broad spectrum antifungal. Cycloheximide inhibits protein synthesis by interfering with translocation. Cycloheximide is an established bioprobe and widely-used antifungal reagent in research with over 25,000 literature citations. potent and selective 5-HT uptake inhibitor
