Technology Process of (2S,3S)-2-benzyloxymethyl-3-tert-butyloxirane
There total 4 articles about (2S,3S)-2-benzyloxymethyl-3-tert-butyloxirane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at -20 - 20 ℃;
for 3h;
DOI:10.1021/jo034007l
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / L-(+)-diisopropyl tartrate; Ti(O-iPr)4; t-BuOOH / molecular sieves 4 Angstroem / CH2Cl2; 2,2,4-trimethyl-pentane / 5 h / -20 °C
2: 100 percent / NaH / dimethylformamide / 3 h / -20 - 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; sodium hydride;
4 A molecular sieve;
In
2,2,4-trimethylpentane; dichloromethane; N,N-dimethyl-formamide;
1: Sharpless epoxidation;
DOI:10.1021/jo034007l
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / DIBALH / diethyl ether; hexane / 3 h / -78 °C
2: 90 percent / L-(+)-diisopropyl tartrate; Ti(O-iPr)4; t-BuOOH / molecular sieves 4 Angstroem / CH2Cl2; 2,2,4-trimethyl-pentane / 5 h / -20 °C
3: 100 percent / NaH / dimethylformamide / 3 h / -20 - 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; sodium hydride; diisobutylaluminium hydride;
4 A molecular sieve;
In
2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
2: Sharpless epoxidation;
DOI:10.1021/jo034007l
