22147-62-2Relevant academic research and scientific papers
Active Base Hybrid Organosilica Materials based on Pyrrolidine Builder Units for Fine Chemicals Production
Llopis, Sebastián,Velty, Alexandra,Díaz, Urbano
, p. 5012 - 5024 (2021/10/19)
The catalytic activity of “pyrrolidine type” fragments included or anchored in the mesoporous silica supports or polymeric frameworks have been fully reported for enantioselective transformation. Nevertheless, low attention was focused on their catalytic abilities to perform base-catalyzed reaction. Accordingly, hybrid materials including pyrrolidine fragments in the mesoporous silica supports were prepared following different synthesis methods, such as micellar and fluoride sol-gel routes in absence of structural directing agents. Their great catalytic performance was explored for various base-catalyzed reactions to the formation of C?C bond through Knoevenagel, Claisen-Schmidt and Henry condensations under microwave irradiation. The benefits of microwave irradiation combined with suitable catalytic properties of pyrrolidine hybrid materials with strong base sites and high accessibility to active centers, allowed carrying out successfully base-catalyzed condensation reactions for the production of fine chemicals. Moreover, the hybrid catalyst exhibited high selectivity and good stability over different catalytic cycles contributing to environmental sustainability.
Stereochemistry of the Reaction of Diorganocuprate(I) Complexes Derived from Grignard Reagents with α,β-Acetylenic Esters
Jalander, Lars,Iambolieva, Kostadinka,Sundstroem, Viola
, p. 715 - 720 (2007/10/02)
Diorganocuprate(I) complexes RCH3CuMgX, prepared from methylcopper and Grignard reagents (i-PrMgBr and t-BuMgCl) gave mainly cis-1,4-addition of the alkyl group originally present in the Grignard reagents and small amounts of cis- and trans-1,4-addition of the methyl group introduced by methylcopper, when they were allowed to react with ethyl propiolate and ethyl phenylpropiolate.The proportion of cis-1,4-addition products did not change when the reaction temperature was raised from -78 deg C to room temperature.The configurations of the main reaction products from the reaction with ethyl phenylpropiolate, ethyl (Z)-β-isopropylcinnamate and ethyl (Z)-β-t-butylcinnamate, were established by conversion of the corresponding acids to β-isopropylindenone and β-t-butylindenone.
