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Phthivazid

Base Information Edit
  • Chemical Name:Phthivazid
  • CAS No.:149-17-7
  • Molecular Formula:C14H13 N3 O3
  • Molecular Weight:271.276
  • Hs Code.:2933399090
  • UNII:40Q4C3O4V0
  • DSSTox Substance ID:DTXSID3020758
  • Wikidata:Q4493190
  • NCI Thesaurus Code:C72604
  • Pharos Ligand ID:LG2N9C43FBHG
  • Mol file:149-17-7.mol
Phthivazid

Synonyms:Acid Vanillylidenehydrazide, Isonicotinic;Ftivazide;Hydrazide, Isonicotinic Acid;Isonex;Isoniazid;Isonicotinic Acid Hydrazide;Isonicotinic Acid Vanillylidenehydrazide;phthivazid;Phthivazide;Tubazide;Vanillylidenehydrazide, Isonicotinic Acid

Suppliers and Price of Phthivazid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • IsonicotinicAcidVanillylidenehydrazide
  • 500mg
  • $ 605.00
  • Sigma-Aldrich
  • ISONICOTINIC 4-HYDROXY-3-METHOXYBENZYLIDENEHYDRAZIDE Aldrich
  • 50mg
  • $ 144.00
Total 14 raw suppliers
Chemical Property of Phthivazid Edit
Chemical Property:
  • Vapor Pressure:5.36E-08mmHg at 25°C 
  • Melting Point:219-220 °C 
  • Refractive Index:1.5700 (estimate) 
  • Boiling Point:441.6°C at 760 mmHg 
  • PKA:8.65±0.35(Predicted) 
  • Flash Point:220.9°C 
  • PSA:83.81000 
  • Density:1.3g/cm3 
  • LogP:1.95060 
  • XLogP3:1.6
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:4
  • Exact Mass:271.09569129
  • Heavy Atom Count:20
  • Complexity:343
Purity/Quality:

99% *data from raw suppliers

IsonicotinicAcidVanillylidenehydrazide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:COC1=C(C=CC(=C1)C=NNC(=O)C2=CC=NC=C2)O
  • Uses Isonicotinic Acid Vanillylidenehydrazide exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and anti-microbial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger.Also, it is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
Technology Process of Phthivazid

There total 3 articles about Phthivazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 2 steps
1: hydrazine hydrate
2: water
With water; hydrazine hydrate;
Guidance literature:
Aldehyd, Hydrazin;
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