S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate

Base Information

• Chemical Name: S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate
• CAS No.: 1017238-08-2
• Molecular Formula: C₃₀H₄₆O₃SSi
• Molecular Weight: 514.845
• Mol file: 1017238-08-2.mol

Synonyms:S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate

Chemical Property of S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate

There total 1 articles about S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

S-ethyl (2E,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxydec-2-enethioate (1017238-07-1) + methylmagnesium bromide (75-16-1) → S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate (1017238-08-2)

Guidance literature:

methylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; (R)-1-[(S_p)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; In diethyl ether; tert-butyl methyl ether; at -75 ℃; for 0.166667h; Inert atmosphere;

S-ethyl (2E,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxydec-2-enethioate; In diethyl ether; tert-butyl methyl ether; at -75 ℃; for 15h; Inert atmosphere;

DOI:10.1021/ol8001255

Reference yield: 95.0%

S-ethyl (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanethioate (1017238-08-2) → (3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanal (1017238-09-3)

Guidance literature:

With triethylsilane; 10% Pd/C; In dichloromethane; at 20 ℃; for 30h; Inert atmosphere;

DOI:10.1021/ol8001255

upstream raw materials:

S-ethyl (2E,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxydec-2-enethioate

methylmagnesium bromide

Downstream raw materials:

(3S,5S,7S)-7-{[tert-butyl(diphenyl)silyl]oxy}-5-methoxy-3-methyldecanal