Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

Base Information

Chemical Name:Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate
CAS No.:1092938-35-6
Molecular Formula:C₂₅H₂₅FN₄O₄
Molecular Weight:464.496
Hs Code.:

Synonyms:Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

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Chemical Property of Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

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Technology Process of Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

There total 6 articles about Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 1073630-64-4
6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester

: 174669-73-9
(2-fluoro-pyridin-3-yl)boronic acid

: 1092938-35-6
Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 70 ℃; for 16h;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1092938-35-6
Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethylammonium chloride; potassium fluoride / dichloromethane; xylene / 15 h / 160 °C

2.1: ethanol / 0.17 h / 85 °C

2.2: 15 h / 85 °C

3.1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

4.1: potassium carbonate / acetonitrile / 18 h / Reflux

5.1: N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 16 h / 70 °C

With potassium fluoride; N-Bromosuccinimide; N,N-dimethylammonium chloride; potassium carbonate; N,N-diethylaniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrachloromethane; ethanol; dichloromethane; water; toluene; acetonitrile; xylene;

Reference yield:

: 127143-28-6
(Z)-1-(2-chloro-2-nitrovinyl)-4-methoxybenzene

: 1092938-35-6
Methyl 6-{[6-(2-fluoropyridin-3-yl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}-hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 0.17 h / 85 °C

1.2: 15 h / 85 °C

2.1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

3.1: potassium carbonate / acetonitrile / 18 h / Reflux

4.1: N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 16 h / 70 °C

With N-Bromosuccinimide; potassium carbonate; N,N-diethylaniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrachloromethane; ethanol; water; toluene; acetonitrile;