3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

Base Information

Chemical Name:3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole
CAS No.:1400592-19-9
Molecular Formula:C₂₂H₁₇F₂N₃
Molecular Weight:361.394
Hs Code.:

Synonyms:3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

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Chemical Property of 3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

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Technology Process of 3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

There total 4 articles about 3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1400592-08-6
C₂₂H₁₅F₂NO

: 1400592-19-9
3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

Guidance literature:: With hydrazine hydrate; In ethanol; Reflux;
DOI:10.1016/j.bmcl.2012.07.080

Reference yield:

: 86-74-8,105184-46-1,97960-57-1
9H-carbazole

: 1400592-19-9
3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C

2: trichlorophosphate / 3 h / 75 - 80 °C

3: sodium hydroxide / ethanol / 24 h / 20 °C

4: hydrazine hydrate / ethanol / Reflux

With sodium hydride; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; 2: |Vilsmeier-Haack Formylation / 3: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2012.07.080

Reference yield:

: 1484-12-4
N-methylcarbazole

: 1400592-19-9
3-(3-(3,4-difluorophenyl)-4,5-dihydro-1H-pyrazol-5-yl)-9-methyl-9H-carbazole

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / 75 - 80 °C

2: sodium hydroxide / ethanol / 24 h / 20 °C

3: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; sodium hydroxide; trichlorophosphate; In ethanol; 1: |Vilsmeier-Haack Formylation / 2: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2012.07.080