4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

Base Information

Chemical Name:4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid
CAS No.:113522-69-3
Molecular Formula:C₂₉H₃₈O₄Si
Molecular Weight:478.704
Hs Code.:

Synonyms:4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

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Chemical Property of 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

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Technology Process of 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

There total 7 articles about 4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113522-65-9
2-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-butyl]-6,6-dimethyl-cyclohex-2-enone

: 113522-69-3
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

Guidance literature:: With jones reagent; In acetone; at 20 ℃; for 1h;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 77661-80-4
2-(2-(benzyloxy)ethyl)propane-1,3-diol

: 113522-69-3
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

2: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

3: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

4: Et₃N / methanol / 12 h / 20 °C

5: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

6: Jones reagent / acetone / 1 h / 20 °C

With 1H-imidazole; jones reagent; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)96293-2

Reference yield:

: 113522-59-1
CH(CH₂CH₂OBn)(CO₂Me)2

: 113522-69-3
4-(tert-Butyl-diphenyl-silanyloxy)-3-(5,5-dimethyl-6-oxo-cyclohex-1-enylmethyl)-butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / BH₃ - dimethyl sulfide / tetrahydrofuran / 9 h / 75 °C

2: 92 percent / Bu₂SnO (stannylene acetal) Bu₄NBr / toluene / 18 h / Heating

3: 92 percent / Ph₃P, imidazole, I₂ / tetrahydrofuran / 1 h / 20 °C

4: 2.) p-TsOH / 1.) THF, -78 deg C to 20 deg C, 5h; 2.) 5h, 20 deg C

5: Et₃N / methanol / 12 h / 20 °C

6: 71 percent / boron tribromide / CH₂Cl₂ / 0.25 h / 0 °C

7: Jones reagent / acetone / 1 h / 20 °C

With 1H-imidazole; jones reagent; dimethylsulfide borane complex; Bu₂SnO (stannylene acetal) Bu₄NBr; iodine; boron tribromide; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene;
DOI:10.1016/S0040-4039(00)96293-2