4-METHOXY-1-METHYLINDOLE

Base Information

• Chemical Name: 4-METHOXY-1-METHYLINDOLE
• CAS No.: 7556-35-6
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 29339980
• Mol file: 7556-35-6.mol

Synonyms:Indole,4-methoxy-1-methyl- (7CI,8CI);1-Methyl-4-methoxyindole;4-Methoxy-1-methyl-1H-indole;4-Methoxy-1-methylindole;

Chemical Property of 4-METHOXY-1-METHYLINDOLE

Chemical Property:

• Vapor Pressure: 0.00479mmHg at 25°C
• Melting Point: 89-91 °C
• Refractive Index: 1.551
• Boiling Point: 285.6°C at 760 mmHg
• Flash Point: 126.5°C
• PSA: 14.16000
• Density: 1.06g/cm³
• LogP: 2.18690
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxy-1-methylindole 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Methoxy-1-methylindole has been used:as internal standard for the quantification of indole-3-carbinol acetate, indole-3-carbinol and 3,3′-diindolylmethane in mouse plasma, liver and kidney tissues by HPLCin preparation of ethyl 9-methoxy-3,4,5-trimethylpyrrolo[3,2-b]carbazole-2-carboxylate

Technology Process of 4-METHOXY-1-METHYLINDOLE

There total 12 articles about 4-METHOXY-1-METHYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-1H-indole (4837-90-5) + methyl iodide (74-88-4) → 4-methoxy-1-methyl-1H-indole (7556-35-6)

Guidance literature:

4-methoxy-1H-indole; With sodium hydride; In acetonitrile; at 0 ℃; for 0.5h;

methyl iodide; In acetonitrile; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.orglett.9b02612

Reference yield: 89.0%

4-methoxy-1H-indole (4837-90-5) + trifluoroacetic acid-methyl ester (431-47-0) → 4-methoxy-1-methyl-1H-indole (7556-35-6)

Guidance literature:

4-methoxy-1H-indole; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

trifluoroacetic acid-methyl ester; In N,N-dimethyl-formamide; for 10h;

Reference yield: 74.0%

1H-indol-4-ol (2380-94-1) + methyl iodide (74-88-4) → 4-methoxy-1-methyl-1H-indole (7556-35-6)

Guidance literature:

1H-indol-4-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ol0490072 DOI:10.1021/ja043273t

upstream raw materials:

4-methoxy-1-methyloxindole

4-methoxy-1H-indole

methyl iodide

1H-indol-4-ol

Downstream raw materials:

4-hydroxy-N-methyl-indole

(4-methoxy-1-methyl-1H-indol-3-yl)(phenyl)methanone

4-methoxy-1-methyl-1H-indole-2,3-dione

4-methoxy-1-methyl-1H-indole-3-carbaldehyde