4-Methoxy-1-methylindolin-2-one

Base Information

• Chemical Name: 4-Methoxy-1-methylindolin-2-one
• CAS No.: 7699-21-0
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• DSSTox Substance ID: DTXSID301251576
• Mol file: 7699-21-0.mol

Synonyms:4-Methoxy-1-methylindolin-2-one;7699-21-0;4-methoxy-1-methyl-3H-indol-2-one;SCHEMBL751029;QRGVWBMIQHILSZ-UHFFFAOYSA-N;DTXSID301251576;MFCD13178646;SB64478;4-Methoxy-1-methyl-1,3-dihydroindol-2-one;4-methoxy-1-methyl-1,3-dihydro-indol-2-one;E84953;1,3-Dihydro-4-methoxy-1-methyl-2H-indol-2-one;4-methoxy-1-methyl-1,3-dihydro-2H-indol-2-one;A1-00709

Chemical Property of 4-Methoxy-1-methylindolin-2-one

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 217

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-1-methylindolin-2-one 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C(=O)CC2=C1C=CC=C2OC

Technology Process of 4-Methoxy-1-methylindolin-2-one

There total 16 articles about 4-Methoxy-1-methylindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-chloroacetyl-N-methyl-m-anisidine (65836-81-9) → 6-methoxy-1-methylindolin-2-one (7703-91-5) + 4-methoxy-1-methyloxindole (7699-21-0)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile; Irradiation;

DOI:10.1248/cpb.29.128

Reference yield:

4-methoxyindolin-2-one (7699-17-4) + methyl iodide (74-88-4) → 4-methoxy-1-methyloxindole (7699-21-0)

Guidance literature:

With sodium methylate; Behandeln des Reaktionsprodukts mit wss.Natronlauge;

Reference yield:

4-methoxy-1-methyl-1H-indole (7556-35-6) → 4-methoxy-1-methyloxindole (7699-21-0)

Guidance literature:

4-methoxy-1-methyl-1H-indole; With water; bromine; potassium bromide; In tert-butyl alcohol; for 0.5h;

With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; for 18h;

upstream raw materials:

4-methoxyindolin-2-one

methyl iodide

4-methyl-4H-benzo[1,4]oxazin-3-one

N-chloroacetyl-N-methyl-o-anisidine

Downstream raw materials:

4-methoxy-1-methyl-2,3-dihydro-indole

4-methoxy-1-methyl-1H-indole

4-Methoxy-1-methyl-2-thioxo-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

Acetic acid 1-methyl-3-phenylcarbamoyl-2-thioxo-2,3-dihydro-1H-indol-4-yl ester