(Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide

Base Information

• Chemical Name: (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide
• CAS No.: 848150-59-4
• Molecular Formula: C₂₀H₂₁FN₂O₄
• Molecular Weight: 372.396
• Mol file: 848150-59-4.mol

Synonyms:(Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide

Chemical Property of (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide

There total 3 articles about (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide (848150-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic anhydride / 70 - 80 °C

2: CHCl₃; H₂O / 1 h / cooling

With sodium acetate; In chloroform; water; acetic anhydride;

DOI:10.3987/COM-04-10242

Reference yield:

[2-(4-fluoro-phenyl)-acetylamino]-acetic acid (10457-87-1) → (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide (848150-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic anhydride / 70 - 80 °C

2: CHCl₃; H₂O / 1 h / cooling

With sodium acetate; In chloroform; water; acetic anhydride;

DOI:10.3987/COM-04-10242

Reference yield:

methylamine (74-89-5) + (Z)-4-(3,4-dimethoxybenzylidene)-2-(4-fluorobenzyl)-5(4H)-oxazolone (622787-45-5) → (Z)-3-(3,4-dimethoxyphenyl)-2-(4-fluorophenylacetylamino)-N-methyl-2-propenamide (848150-59-4)

Guidance literature:

In chloroform; water; for 1h; cooling;

DOI:10.3987/COM-04-10242

upstream raw materials:

methylamine

(Z)-4-(3,4-dimethoxybenzylidene)-2-(4-fluorobenzyl)-5(4H)-oxazolone

3,4-dimethoxy-benzaldehyde

[2-(4-fluoro-phenyl)-acetylamino]-acetic acid