3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

Base Information

Chemical Name:3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester
CAS No.:875473-35-1
Molecular Formula:C₂₂H₂₇O₇P
Molecular Weight:434.426
Hs Code.:

Synonyms:3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

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Chemical Property of 3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

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Technology Process of 3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

There total 10 articles about 3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 875473-34-0
allyl 3-{3-[4-(chloromethyl)phenoxy]-4-methoxyphenyl}propanoate

: 512-56-1
trimethyl phosphite

: 875473-35-1
3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

Guidance literature:: for 20h; Heating;
DOI:10.1039/b513515j

Reference yield:

: 621-59-0
isovanillin

: 875473-35-1
3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / CH₂Cl₂ / 22 h

2: 91 percent / HCO₂NH₄ / Pd/C / methanol / 3 h / Heating

3: 68 percent / Et₃N; Cu(OAc)2; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

4: 143 mg / Bu₂SnO / 20 h / Heating

5: 106 mg / NaBH₄ / methanol / 1.5 h / 0 °C

6: 90 percent / thionyl chloride / CH₂Cl₂ / 2 h / 0 °C

7: 91 percent / 20 h / Heating

With sodium tetrahydroborate; thionyl chloride; copper diacetate; 4 A molecular sieve; ammonium formate; di(n-butyl)tin oxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Wittig reaction;
DOI:10.1039/b513515j

Reference yield:

: 16980-82-8
3-(3-hydroxy-4-methoxyphenyl)-acrylic acid methyl ester

: 875473-35-1
3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / HCO₂NH₄ / Pd/C / methanol / 3 h / Heating

2: 68 percent / Et₃N; Cu(OAc)2; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

3: 143 mg / Bu₂SnO / 20 h / Heating

4: 106 mg / NaBH₄ / methanol / 1.5 h / 0 °C

5: 90 percent / thionyl chloride / CH₂Cl₂ / 2 h / 0 °C

6: 91 percent / 20 h / Heating

With sodium tetrahydroborate; thionyl chloride; copper diacetate; 4 A molecular sieve; ammonium formate; di(n-butyl)tin oxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/b513515j