(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

Base Information

Chemical Name:(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol
CAS No.:1395280-45-1
Molecular Formula:C₂₀H₃₆N₂O₂Si
Molecular Weight:364.604
Hs Code.:

Synonyms:(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

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Chemical Property of (1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

There total 13 articles about (1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (±)-(1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

: 1395280-45-1
(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

: 1395280-43-9
(1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

Guidance literature:: With Chiralpak column; In ethanol; carbon dioxide; 2,2'-iminobis[ethanol]; at 40 ℃;

Reference yield:

: 1187055-95-3
(±)-5-methyl-3-(3-nitropyridin-4-yl)cyclohex-2-enone

: 1395280-45-1
(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

: 1395280-43-9
(1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: dichloromethane / 19 h / 0 - 20 °C

2.2: 0.33 h / 0 °C

2.3: 1 h / 0 °C

3.1: methyl iodide / tetrahydrofuran / 18 h / 0 - 20 °C

3.2: 5 h / 20 °C

4.1: sodium tetrahydroborate; methanol; cerium(III) chloride heptahydrate / 1.5 h / 0 - 20 °C

5.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

6.1: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; acetone / 1 h / 20 °C

7.1: Dess-Martin periodane / dichloromethane / 72 h / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 50 °C / Inert atmosphere

8.2: 3 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

10.1: Chiralpak column / ethanol; carbon dioxide; 2,2'-iminobis[ethanol] / 40 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; potassium tert-butylate; hydrogen; Dess-Martin periodane; 4-methylmorpholine N-oxide; lithium hexamethyldisilazane; methyl iodide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; 2,2'-iminobis[ethanol]; acetone;

Reference yield:

: 1395280-14-4
(±)-5-methyl-6-methylene-3-(3-nitropyridin-4-yl)cyclohex-2-enone

: 1395280-45-1
(1S,2S,4S,6R)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

: 1395280-43-9
(1R,2R,4R,6S)-4-(3-aminopyridin-4-yl)-2-(tert-butyldimethylsilyloxy)-1-ethyl-6-methylcyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; methanol; cerium(III) chloride heptahydrate / 1.5 h / 0 - 20 °C

2.1: 1H-imidazole / dichloromethane / 18 h / 20 °C

3.1: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; acetone / 1 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 72 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 50 °C / Inert atmosphere

5.2: 3 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

7.1: Chiralpak column / ethanol; carbon dioxide; 2,2'-iminobis[ethanol] / 40 °C

With 1H-imidazole; methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate; potassium tert-butylate; hydrogen; Dess-Martin periodane; 4-methylmorpholine N-oxide; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; 2,2'-iminobis[ethanol]; acetone;