[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Base Information

Chemical Name:[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine
CAS No.:1240608-51-8
Molecular Formula:C₂₄H₁₉FN₄O₂
Molecular Weight:414.439
Hs Code.:

Synonyms:[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

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Technology Process of [2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

There total 7 articles about [2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 958245-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

: 1381869-39-1
4-bromo-2-(4-fluorophenyl)benzo[d]oxazole

: 1240608-51-8
[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm201710f

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1240608-51-8
[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 6 h / 150 °C / Autoclave; Inert atmosphere

2: 10% Pd/C; hydrogen / methanol / 12 h / 50 °C / 760.05 Torr

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10% Pd/C; hydrogen; potassium carbonate; caesium carbonate; XPhos; In methanol; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/jm201710f

Reference yield:

: 1381869-38-0
N-(2,6-dibromophenyl)-4-fluorobenzamide

: 1240608-51-8
[2-(4-fluorophenyl)benzoxazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / 1,2-dimethoxyethane / 90 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; XPhos; In 1,2-dimethoxyethane; tert-butyl alcohol;
DOI:10.1021/jm201710f