methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate

Base Information

• Chemical Name: methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate
• CAS No.: 1402160-20-6
• Molecular Formula: C₃₁H₃₂N₂O₄
• Molecular Weight: 496.606
• Mol file: 1402160-20-6.mol

Synonyms:methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate

Chemical Property of methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate

There total 5 articles about methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

6-methoxy-6-oxohexan-1-aminium chloride + 3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylic acid (1402160-17-1) → methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate (1402160-20-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 98h;

Reference yield: 37.0%

3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylic acid (1402160-17-1) + methyl 6-aminocaproate hydrochloride (1926-80-3) → methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate (1402160-20-6)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 98h;

Reference yield:

(E)-N-benzylideneglycine methyl ester (66646-88-6,120238-40-6,138495-05-3) → methyl 6-[3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate (1402160-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; silver(I) acetate / 20 °C

1.2: 48 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / 1,2-dimethoxyethane; ethanol; water

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 98 h / 0 - 20 °C

With 4-methyl-morpholine; silver(I) acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

(E)-1-(benzyloxy)-4-(2-nitrovinyl)benzene

(E)-N-benzylideneglycine methyl ester

3-(4-benzyloxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylic acid

5-phenyl-3-(4-benzyloxyphenyl)-2-methoxycarbonyl-1H-pyrrole

Downstream raw materials:

N-(6-(hydroxyamino)-6-oxohexyl)-3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamide

methyl 6-[3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate