Phosphorodichloridous acid, propyl ester

Base Information

• Chemical Name: Phosphorodichloridous acid, propyl ester
• CAS No.: 13040-68-1
• Molecular Formula: C₃H₇Cl₂OP
• Molecular Weight: 160.968
• European Community (EC) Number: 603-415-0
• DSSTox Substance ID: DTXSID801277002
• Mol file: 13040-68-1.mol

Synonyms:Phosphorodichloridous acid, propyl ester;dichloro-n-propoxy phosphine;Propyl dichloridophosphite #;SCHEMBL11125255;DTXSID801277002;Phosphorodichloridous acid propyl ester;13040-68-1

Chemical Property of Phosphorodichloridous acid, propyl ester

Chemical Property:

• Vapor Pressure: 7.28mmHg at 25°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 159.9611572
• Heavy Atom Count: 7
• Complexity: 41.9

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCOP(Cl)Cl

Technology Process of Phosphorodichloridous acid, propyl ester

There total 5 articles about Phosphorodichloridous acid, propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

propan-1-ol (71-23-8) → n-propyl dichlorophosphite (13040-68-1)

Guidance literature:

With phosphorus trichloride; In diethyl ether; at -78 - 20 ℃; for 0.25h;

DOI:10.1080/10426500307817

Reference yield: 69.0%

trimethyl(propoxy)silane (1825-63-4) → n-propyl dichlorophosphite (13040-68-1)

Guidance literature:

With pyridine; phosphorus trichloride; In dichloromethane; at -65 - 20 ℃; for 27h; Inert atmosphere; Sealed tube;

DOI:10.1080/10426500902719222

Reference yield: 60.0%

dipropyl phosphorochloridite (20003-39-8) → n-propyl dichlorophosphite (13040-68-1)

Guidance literature:

With phosphorus trichloride; at 100 ℃; for 8h;

upstream raw materials:

propan-1-ol

tri-n-propyl phosphite

dipropyl phosphorochloridite

trimethyl(propoxy)silane

Downstream raw materials:

Acetylphosphonsaeure-propylester-(dimethyl-phenyl-silylester)

(Benzyloxycarbonylamino-phenyl-methyl)-phosphonic acid monopropyl ester

propan-1-ol

cyclohexylphenylimine hydrochloride

Refernces

• 1、 Lu, Haiyan,Ng, Rudy J.,Shieh, Charlene C.,Martinez, Alicia R.,Berkman, Clifford E.. "Inhibition of glutamate carboxypeptidase by phosphoryl and thiophosphoryl derivatives of glutamic and 2-hydroxyglutaric acid". . p. 17 - 32. Retrieved 2007/10/03.